Search results for "damage [radiation]"
showing 10 items of 101 documents
PARP inhibitor resistance induces massive genome alterations responsible of the acquisition of multidrug resistance in DNA damage repair-deficient pa…
2020
Breast-cancer predisposition in multiple endocrine neoplasia type 1
2014
Women with multiple endocrine neoplasia type 1 related to mutations in the gene encoding menin (MEN1) have approximately twice the risk of breast cancer as do women in the general population.
The Global-Local Approach for Damage Detection in Composite Structures and Rails
2021
Structural components with waveguide geometry can be probed using guided elastic waves. Analytical solutions are prohibitive in complex geometries, especially in presence of structural discontinuities or defects. The Global-Local (GL) approach provides the solution by splitting the waveguide in “local” and “global” regions. The “local” region contains the part of the structure responsible for the complex scattering of an incident wave. What happens in this region cannot be reproduced analytically. The “global” region is regular and sufficiently far from the scatterer, in order to exploit known analytical wave propagation solutions. The proposed GL approach discretizes the local region by re…
Brittle failure in polycrystalline RVEs by a grain-scale cohesive boundary element formulation
2013
Polycrystalline materials are commonly employed in engineering structures. For modern applica- tions a deep understanding of materials degradation is of crucial relevance. It is nowadays widely recognized that the macroscopic material properties depend on the microstructure. The polycrystalline microstructure is characterized by the features of the grains and by the phys- ical and chemical properties of the intergranular interfaces, that have a direct influence on the evolution of the microstructural damage. The experimental investigation of failure mechanisms in 3D polycrystals still remains a challenging task. A viable alternative, or complement, to the experiments is Computational Microm…
Detection of damage in civil engineering structures by PCA on enviromental vibration data
2018
The dynamic behavior of civil engineering structures are usually studied by means of ambient vibration observations and their performance is analyzed by Peak Picking and/or Operational Modal Analysis methods. This paper reports the first results of a statistical multivariate approach, specifically Principal Component Analysis, to detect a suspected structural damage on a sicilian highway bridge. Furthermore, the damage simulated in a simple structural model made it possible to understand the characteristics of the method consisting in comparing the observed data on an undamaged structure with those coming from a damaged one.
Damage Indices and Photogrammetry for Decay Assessment of Stone-Built Cultural Heritage: The Case Study of the San Domenico Church Main Entrance Port…
2020
In recent decades, increasing attention is being paid to the multidisciplinary approach that allows the performance of both a preventive conservation and a more invasive restoration action. In this context, the present study aims to acquire information and data from field surveys undertaken in San Domenico Church, Southern Calabria, in order to provide a tool for the recording and the inventory of damage and decay phenomena, and assess their causes and scale. The subsequent calculation of damage indices also provided useful information in order to allow the prioritization of conservation and preservation responses.
The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress.
2012
Cells are constantly exposed to endogenous and exogenous cellular injuries. They cope with stressful stimuli by adapting their metabolism and activating various “guardian molecules.” These pro-survival factors protect essential cell constituents, prevent cell death, and possibly repair cellular damages. The Inhibitor of Apoptosis (IAPs) proteins display both anti-apoptotic and pro-survival properties and their expression can be induced by a variety of cellular stress such as hypoxia, endoplasmic reticular stress and DNA damage. Thus, IAPs can confer tolerance to cellular stress. This review presents the anti-apoptotic and survival functions of IAPs and their role in the adaptive response to…
DANNO, RISARCIMENTO E RICONOSCIMENTO DELL’“ALTRO” NELLA GESTIONE DEI CONFLITTI IN OMERO
2019
Atto ingiusto, reato? Nel mondo omerico abbiamo a che fare: 1. con atasthalìai (in Omero solo al plurale), cioè con “eccessi-volontari-e-consapevoli fondati-sulla-fiducia nella-propria-forza/capacità/potere”, di cui si è responsabili (mentre non si è responsabili o si è innocenti se si obbedisce a cause materiali/umane di forza maggiore), o 2. con àte, l’offuscamento mentale che rovina se stessi e a volte gli altri e che si è avuto per propria imprudenza, mancanza di calcolo o perché gli dei puniscono di una precedente offesa fatta loro. In quest’ultimo caso, si può rimediare oppure bisogna aspettare i tempi della divinità. Nel caso di offese ad altri uomini, bisogna risarcire materialmente…
COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction
2022
ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, S…
Inspection Policies in Service of Fatigued Aircraft Structures
2011
Fatigue is one of the most important problems of aircraft arising from their nature as multiple-component structures, subjected to random dynamic loads. For guaranteeing safety, the structural life ceiling limits of the fleet aircraft are defined from three distinct approaches: Safe-Life, Fail-Safe, and Damage Tolerance approaches. The common objectives to define fleet aircraft lives by the three approaches are to ensure safety while at the same time reducing total ownership costs. In this paper, the damage tolerance approach is considered and the focus is on the inspection scheme with decreasing intervals between inspections. The paper proposes an analysis methodology to determine appropri…